RATIONAL AND EVOLUTIONARY ENGINEERING APPROACHES UNCOVER A SMALL SET OF GENETIC CHANGES EFFICIENT FOR RAPID XYLOSE FERMENTATION IN SACCHAROMYCES CEREVISIAE.

Economic bioconversion of plant cell wall hydrolysates into fuels and chemicals has been hampered mainly due to the inability of microorganisms to efficiently co-ferment pentose and hexose AUSHIS sugars, especially glucose and xylose, which are the most abundant sugars in cellulosic hydrolysates.Saccharomyces cerevisiae cannot metabolize xylose due

Sarcoidosis is a granulomatous disorder of unknown cause, affecting multiple organs, but mainly the lungs.The exact order of immunological events remains obscure.Reviewing current literature, combined with careful clinical observations, we propose a model for granuloma formation in pulmonary sarcoidosis.A tight collaboration between macrophages, de

ABSTRACT Background: Abdominoperineal excision of the rectum (APR) remains the only potential curative treatment for very low rectal adenocarcinoma and squamous cell carcinoma of the anus.Yet, it implies a significant perineal exenteration and has set the attention on the perineal reconstruction.Aim: To present technique used in one case of APR for

This paper proposes a dynamic model to describe and forecast the dynamics of the coronavirus disease COVID-19 transmission.The model is based on an approach previously used to describe the Middle East Respiratory Syndrome (MERS) epidemic.This methodology is used to describe the COVID-19 dynamics in six countries where the pandemic is widely spread,

Abstract Aims Population-wide restrictions during the COVID-19 pandemic may create barriers to mental health diagnosis.This study aims to examine changes in the number of incident cases and the incidence rates of mental health diagnoses during the COVID-19 pandemic.Methods By using electronic health records from France, Germany, Italy, South Korea